All content on this site is intended for healthcare professionals only. By acknowledging this message and accessing the information on this website you are confirming that you are a Healthcare Professional. If you are a patient or carer, please visit the MPN Advocates Network.
Introducing
Now you can personalise
your MPN Hub experience!
Bookmark content to read later
Select your specific areas of interest
View content recommended for you
Find out moreThe MPN Hub website uses a third-party service provided by Google that dynamically translates web content. Translations are machine generated, so may not be an exact or complete translation, and the MPN Hub cannot guarantee the accuracy of translated content. The MPN Hub and its employees will not be liable for any direct, indirect, or consequential damages (even if foreseeable) resulting from use of the Google Translate feature. For further support with Google Translate, visit Google Translate Help.
Bookmark this article
Several conditioning regimens are available for patients with myelofibrosis (MF) who will undergo allogeneic hematopoietic stem cell transplant (allo-HSCT) in order to manage splenomegaly, hepatic disease, and graft rejection. While busulfan-based conditioning regimens are used frequently, no single conditioning regimen has yet been defined as being the most effective.
Below, we summarize a retrospective analysis by Robin et al.1 published in Nature on March 15, 2024, investigating treosulfan-based regimens compared with busulfan-based regimens in patients with MF who will undergo allo-HSCT from the European Bone Marrow Transplant (EBMT) registry.
Figure 1. Survival outcomes of patients after transplant who received low-dose busulfan, high-dose busulfan, or treosulfan regimens prior to transplant*
GvHD, graft-versus-host disease; HD, high-dose; LD, low-dose; NRM, non-relapse mortality; PFS, progression-free survival; OS, overall survival.
*Adapted from Robin et al.1
Key learnings |
---|
|
Subscribe to get the best content related to MPN delivered to your inbox